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Epithalon
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Telomerase-Activating Tetrapeptide — Longevity Research Compound
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10mg research compound
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Overview
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology as a synthetic analog of the endogenous pineal gland peptide epithalamin. At the molecular level, Epithalon activates telomerase reverse transcriptase (hTERT), the catalytic subunit of the telomerase enzyme responsible for synthesizing telomeric DNA repeats (TTAGGG) at chromosome ends, thereby counteracting the progressive telomere shortening that occurs with each cell division and serves as a primary mechanism of replicative cellular senescence. Published peer-reviewed research demonstrates that Epithalon treatment reactivates telomerase expression in human somatic cells, with studies reporting significant telomere elongation in pulmonary fibroblasts and retinal pigment epithelial cell cultures. Additionally, preclinical literature reports that Epithalon normalizes melatonin secretion patterns from the pineal gland in aging subjects, restoring circadian rhythm architecture and the associated nocturnal growth hormone and cortisol secretion profiles. What distinguishes Epithalon from other telomerase-activating compounds such as TA-65 or cycloastragenol is its peptide-based mechanism that appears to act through direct gene regulation of hTERT transcription rather than through indirect signaling pathways. Clinical studies conducted by Khavinson's group reported reduced cardiovascular mortality and improved biomarkers of aging in elderly cohorts receiving Epithalon-containing preparations over multi-year follow-up periods, though independent replication of these findings is still ongoing in the broader research community.
Handling & Storage
Published research protocols reference subcutaneous or intramuscular administration in 10-20 day cycles. Store refrigerated at 2-8°C. Consult applicable literature for specific research applications.
Published Research Protocols
Published research protocols reference 5-10mg daily for 10-20 day cycles, repeated every 3-6 months. Consult applicable literature for specific research applications.
Research Applications
Telomere Lengthening
Epithalon activates transcription of the hTERT gene encoding the catalytic subunit of telomerase, enabling the enzyme to add TTAGGG hexanucleotide repeats to chromosome ends and counteract replicative telomere erosion. Published research in human fetal fibroblast and retinal pigment epithelial cell cultures demonstrates significant telomere elongation and extension of the Hayflick replicative limit following Epithalon treatment, with cells bypassing the normal senescence checkpoint while maintaining genomic stability.
Initial effects within first month
Circadian Rhythm Regulation
Preclinical and clinical literature demonstrates that Epithalon normalizes melatonin secretion patterns from the aging pineal gland, restoring the nocturnal melatonin peak amplitude that declines significantly with age. This circadian restoration has downstream effects on the hypothalamic-pituitary axis, including normalization of growth hormone pulsatility and cortisol circadian rhythmicity, which are critical regulators of tissue repair, immune function, and metabolic homeostasis during sleep.
Initial effects within first month
Research Studies
Antioxidant Properties
Published research reports that Epithalon enhances the activity of endogenous antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase in aging tissues, reducing oxidative damage to DNA, proteins, and lipid membranes. This antioxidant effect is proposed to operate through both direct enzymatic upregulation and indirect mechanisms via restored melatonin secretion, as melatonin itself is a potent free radical scavenger and mitochondrial antioxidant.
Initial effects within first month
Frequently Asked Questions
What makes your peptides research-grade?
Our Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) synthesized in FDA-registered, cGMP-compliant facilities in the USA. Each batch undergoes HPLC purity analysis (99%+), mass spectrometry to confirm the 390.35 Da molecular weight, and amino acid composition analysis to verify the correct four-residue sequence. This ensures batch-to-batch consistency critical for telomerase activation research.
How long does the product remain stable?
Epithalon in lyophilized form stored at -20°C remains stable for up to 24 months. As a short tetrapeptide, Epithalon is relatively resistant to degradation compared to larger peptides, but the aspartate residue can undergo isomerization in aqueous solution over time. Once reconstituted, store at 2-8°C and use within 30 days. For multi-cycle research protocols spanning months, maintain the lyophilized stock frozen and reconstitute fresh for each cycle.
What is included with my order?
Each order includes Epithalon in lyophilized form at the specified dosage, a Certificate of Analysis (COA) from Janoshik Analytical Laboratory, and detailed storage and reconstitution instructions. The 10mg vial supports standard 10-day cycle protocols at published dosages, while the 50mg vial accommodates multiple cycles or higher-dose research designs. Bacteriostatic water is sold separately.
Do you offer bulk or wholesale pricing?
Yes, we offer volume discounts for research institutions and bulk orders of Epithalon. Given that published research protocols typically reference 10-20 day cycles repeated every 3-6 months, many researchers order multi-cycle quantities. Contact support@pepcelllabs.com for wholesale pricing and custom quantities.
Is this product for human use?
Epithalon is sold strictly for in-vitro research, laboratory use, and educational purposes. While clinical studies have been conducted in Russia by Professor Khavinson's group with reported outcomes in elderly populations, Epithalon has not undergone FDA-regulated clinical trials and is not approved as a therapeutic agent in any Western regulatory jurisdiction. This product is not intended for human consumption or self-administration. Always consult applicable regulations in your jurisdiction.
Important Notice
Not for human consumption. This product is sold exclusively for in-vitro research and laboratory use. It is not a drug, supplement, food item, or cosmetic and has not been evaluated by the FDA.
The research data and clinical references cited on this page are provided for educational reference only and do not constitute medical advice. This product must be handled by qualified research professionals in accordance with all applicable institutional and regulatory guidelines.
Use is restricted to qualified researchers or laboratories operating within appropriate legal and ethical research guidelines. By purchasing, you confirm you are acquiring this product solely for lawful research purposes.
Research Articles
Published research and educational content related to Epithalon
