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Selank
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Anxiolytic Peptide for Calm Focus and Cognitive Clarity
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5mg research compound
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Overview
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as a stabilized analog of tuftsin (Thr-Lys-Pro-Arg), the endogenous immunomodulatory tetrapeptide derived from the Fc domain of immunoglobulin G. The Pro-Gly-Pro C-terminal extension confers resistance to aminopeptidase degradation, significantly extending Selank's biological half-life compared to native tuftsin. At the molecular level, published peer-reviewed research demonstrates that Selank modulates GABAergic neurotransmission by allosterically enhancing GABA-A receptor sensitivity, increases serotonin metabolism in the frontal cortex and hippocampus, and stabilizes brain-derived neurotrophic factor (BDNF) mRNA expression — collectively producing anxiolytic-like effects in preclinical behavioral models including elevated plus maze, open field, and conflict paradigms without sedation, motor impairment, or dependence potential. Additionally, Selank retains the immunomodulatory properties of its parent compound tuftsin, enhancing monocyte phagocytic activity, IL-6 production, and natural killer cell function. What distinguishes Selank from other anxiolytic compounds is its dual neurotropic-immunomodulatory profile — it simultaneously modulates anxiety-related neurotransmitter systems and innate immune function through a single peptide, a combination not achieved by conventional anxiolytic drugs. Selank has been approved as a registered medication in Russia for anxiety and neurasthenia, and current scientific investigation continues in stress-related cognitive impairment, immune-brain axis signaling, and gene expression profiling of Selank-responsive neuronal pathways.
Handling & Storage
Published research protocols reference intranasal administration 2-3 times daily. Store refrigerated at 2-8°C.
Published Research Protocols
Published research protocols reference 200-400mcg intranasally 2-3 times daily. Consult applicable literature for specific research applications.
Research Applications
Anxiolytic Effect
Published preclinical behavioral studies demonstrate that Selank produces anxiolytic-like effects in elevated plus maze, open field, and Vogel conflict paradigms comparable in magnitude to benzodiazepines, but critically without sedation, motor impairment, amnesia, or physical dependence potential. The anxiolytic mechanism involves allosteric modulation of GABA-A receptor sensitivity combined with stabilization of serotonin metabolism in the frontal cortex, providing a dual-pathway approach to anxiety-related neurotransmitter imbalance.
Initial effects within first month
Research Studies
GABA Modulation
Selank enhances GABAergic inhibitory neurotransmission by increasing GABA-A receptor sensitivity to endogenous GABA without directly binding the benzodiazepine site, thereby improving the balance between excitatory and inhibitory neural signaling. Published research demonstrates that this allosteric modulation produces calming effects while preserving cognitive clarity and psychomotor performance — a pharmacological profile that distinguishes Selank from conventional GABAergic anxiolytics that impair learning and memory.
Initial effects within first month
Memory Consolidation
Selank improves memory storage and retrieval through its combined effects on monoamine neurotransmitter systems and neurotrophic factor expression. Published research reports stabilization of BDNF mRNA in hippocampal neurons and enhanced serotonin turnover in memory-associated brain regions, supporting improved long-term potentiation and memory trace consolidation. The anxiolytic component may additionally improve cognitive performance by reducing stress-related interference with attentional and mnemonic processes.
Initial effects within first month
Frequently Asked Questions
How should this peptide be stored?
Selank in lyophilized form should be stored at -20°C for long-term stability, where it remains viable for up to 24 months. The Pro-Gly-Pro C-terminal extension provides enhanced protease resistance compared to native tuftsin, contributing to good stability in both lyophilized and reconstituted forms. Once reconstituted, store at 2-8°C and use within 30 days. For intranasal research protocols, preparing single-use aliquots is recommended.
What quality controls are in place?
Every Selank batch is independently tested by Janoshik Analytical Laboratory using HPLC for purity (99%+), mass spectrometry to confirm the heptapeptide sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (MW 751.9 Da), and amino acid composition analysis. The proline-rich sequence is verified to ensure correct folding and receptor binding affinity. Sterility and endotoxin testing are performed on every batch, with COAs available for all products.
Can I see the Certificate of Analysis?
Yes, Certificates of Analysis documenting HPLC purity, mass spectrometry identity confirmation, and sterility testing are available for every Selank batch. You can find them on the product page under the Lab Results section, or contact support@pepcelllabs.com for specific batch documentation.
What is the shelf life after reconstitution?
Once reconstituted for intranasal administration, Selank should be stored at 2-8°C and used within 28-30 days. Selank is relatively stable among heptapeptides due to its proline-rich sequence, which resists common aminopeptidase and carboxypeptidase degradation pathways. However, avoid repeated temperature cycling that can accelerate deamidation of the threonine residue.
Is this product for human use?
Selank is sold strictly for in-vitro research, laboratory use, and educational purposes. While Selank is approved as a registered anxiolytic medication in Russia and has been used clinically for anxiety disorders and neurasthenia since 2009, it has not undergone FDA-regulated clinical trials and is not approved in Western regulatory jurisdictions. This product is not intended for human consumption or self-administration. Always consult applicable regulations in your jurisdiction.
Important Notice
Not for human consumption. This product is sold exclusively for in-vitro research and laboratory use. It is not a drug, supplement, food item, or cosmetic and has not been evaluated by the FDA.
The research data and clinical references cited on this page are provided for educational reference only and do not constitute medical advice. This product must be handled by qualified research professionals in accordance with all applicable institutional and regulatory guidelines.
Use is restricted to qualified researchers or laboratories operating within appropriate legal and ethical research guidelines. By purchasing, you confirm you are acquiring this product solely for lawful research purposes.
