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TB500
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Thymosin Beta-4 Fragment — Angiogenesis & Tissue Repair Research
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$65.00$78.00
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$13.00In Stock — Ships Same Day
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5mg research compound
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Overview
TB-500 is a synthetic 43-amino-acid peptide corresponding to the active region (amino acids 17-23, sequence LKKTETQ) of Thymosin Beta-4 (Tbeta4), a 4.9 kDa naturally occurring protein found in virtually all mammalian cell types with particularly high concentrations in platelets and wound fluid. At the molecular level, TB-500 functions primarily through its interaction with G-actin (globular actin), sequestering actin monomers to promote cytoskeletal reorganization and upregulate cell migration — the critical first step in tissue repair cascades. Published peer-reviewed literature demonstrates that TB-500 promotes angiogenesis by stimulating endothelial cell differentiation and tubule formation, enhances keratinocyte and fibroblast migration to wound sites, and downregulates inflammatory cytokines including IL-1beta and TNF-alpha at injury loci. Preclinical studies have reported accelerated healing in models of dermal wounds, corneal injuries, cardiac tissue following ischemic events, and musculotendinous injuries, with histological analysis showing improved collagen deposition and reduced fibrotic scar formation. What distinguishes TB-500 from other tissue repair peptides such as BPC-157 is its primary mechanism through actin polymerization regulation and its pronounced effect on cardiac and vascular tissues, whereas BPC-157 acts predominantly through growth factor receptor and NO system pathways. The compound is currently the subject of ongoing preclinical investigation, with particular research interest in its cardioprotective properties and its synergistic potential when studied alongside complementary recovery peptides.
Handling & Storage
Published research protocols reference subcutaneous administration in loading and maintenance phases. Store refrigerated at 2-8°C. Consult applicable literature for specific research applications.
Published Research Protocols
Published research protocols reference 2-2.5mg in loading phases and 2mg in maintenance phases. Consult applicable literature for specific research applications.
Research Applications
New Blood Vessel Formation
TB-500 promotes angiogenesis by stimulating endothelial cell migration, differentiation, and tubule formation through upregulation of VEGF and hypoxia-inducible factor 1-alpha (HIF-1alpha) pathways. Preclinical research demonstrates accelerated capillary network formation at injury sites, restoring nutrient and oxygen delivery to ischemic tissues and establishing the vascular infrastructure necessary for sustained tissue repair.
Initial effects within first month
Research Studies
Connective Tissue Repair
Published preclinical studies demonstrate that TB-500 accelerates healing of tendons, ligaments, and skeletal muscle by promoting cell migration through G-actin sequestration and cytoskeletal reorganization. Research in equine and rodent models reports improved tensile strength recovery and enhanced collagen fiber alignment at tendon injury sites, with earlier return of functional biomechanical properties compared to untreated controls.
Initial effects within first month
Research Studies
Reduced Scar Tissue
TB-500 has been investigated for its ability to minimize fibrotic scar formation by modulating the ratio of collagen type III to collagen type I deposition during the remodeling phase of wound healing. Preclinical wound models report reduced myofibroblast differentiation and decreased alpha-smooth muscle actin expression, resulting in more organized tissue architecture that more closely resembles native uninjured tissue.
Initial effects within first month
Research Studies
Frequently Asked Questions
How should I store this peptide?
TB-500 in lyophilized form should be stored at -20°C for long-term stability, where it remains viable for up to 24 months. Once reconstituted with bacteriostatic water, store at 2-8°C and use within 30 days. TB-500 is moderately sensitive to repeated freeze-thaw cycles due to its 43-amino-acid length, so aliquoting reconstituted solutions into single-use volumes is recommended for multi-week research protocols.
What purity level is this product?
Our TB-500 is verified at 99%+ purity through independent third-party HPLC analysis at Janoshik Analytical Laboratory. Each batch is additionally confirmed via mass spectrometry to verify the molecular weight corresponding to the active Tbeta4 fragment sequence (LKKTETQ region), along with sterility and endotoxin screening. Certificates of Analysis are available for every batch.
How is the dosage calculated for the 30-day supply?
TB-500 vial quantities are formulated based on published research protocols that typically reference 2-2.5mg loading doses and 2mg maintenance doses. The 5mg vial supports lower-dose or shorter research designs, while the 10mg vial accommodates extended protocols including both loading and maintenance phases described in the preclinical literature.
Do you ship internationally?
Currently we ship to all 50 US states with free standard shipping. Express shipping (2-3 business days) is available for $9.99. TB-500 ships as a stable lyophilized powder that tolerates standard transit conditions. International shipping is coming soon.
Is this product for human use?
TB-500 is sold strictly for in-vitro research, laboratory use, and educational purposes. While Thymosin Beta-4 is a naturally occurring and extensively studied mammalian protein with a substantial preclinical research base, no completed large-scale human clinical trials for the synthetic TB-500 fragment have been reported. This product is not intended for human consumption or self-administration. Always consult applicable regulations in your jurisdiction.
Important Notice
Not for human consumption. This product is sold exclusively for in-vitro research and laboratory use. It is not a drug, supplement, food item, or cosmetic and has not been evaluated by the FDA.
The research data and clinical references cited on this page are provided for educational reference only and do not constitute medical advice. This product must be handled by qualified research professionals in accordance with all applicable institutional and regulatory guidelines.
Use is restricted to qualified researchers or laboratories operating within appropriate legal and ethical research guidelines. By purchasing, you confirm you are acquiring this product solely for lawful research purposes.
Research Articles
Published research and educational content related to TB500
Research11 min read
BPC-157 vs TB-500: Comparing Recovery Research Peptides
A detailed comparison of two of the most studied recovery peptides in preclinical research, examining their distinct mechanisms, published findings, and how investigators approach studying them individually and in combination.
Dr. Sarah ChenChief Science Officer
Wellness15 min read
Recovery Peptides: What Preclinical Research Reveals
A review of preclinical research on peptides like BPC-157 and TB-500 and their potential roles in tissue repair and recovery processes.
Dr. Sarah ChenChief Science Officer
Guides11 min read
How to Read a Certificate of Analysis: Peptide Purity Testing Explained
A detailed guide to understanding Certificates of Analysis for research peptides, including HPLC purity, mass spectrometry validation, endotoxin testing, and key red flags that indicate quality issues.
Dr. Sarah ChenChief Science Officer
Education14 min read
A Beginner's Guide to Peptides: What They Are and How They Work
New to the world of peptides? This guide covers the fundamentals of peptide science, their biological roles, and why they have become a focus of modern wellness research.
Michael TorresContent Director
